Activation of autosomal recessive Pseudohypoaldosteronism1 ENaC with aldosterone
نویسندگان
چکیده
منابع مشابه
autosomal recessive disorder
A sibship of a brother and sister with congenital bilateral pseudoglioma is described. The most prominent abnormality was a greyish-white vascularised mass in the retrolental spaces, which was noted as early as the first weeks of life. Corneal opacities, posterior synechiae, and complicated cataracts developed within 1 to 2 years age. The sibship showed normal chromosomes and had no systemic di...
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Aldosterone is involved in salt and water homeostasis. The main effect is thought to involve genomic mechanisms. However, the existence of plasma membrane steroid receptors has been postulated. We used whole cell patch clamp to test the hypothesis that epithelial sodium channels (ENaC) expressed by renal collecting duct principal cells can be regulated nongenomically by aldosterone. In freshly ...
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ژورنال
عنوان ژورنال: European Journal of Pharmacology
سال: 2021
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2021.174090